Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1949362

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human monoamine oxidase A expressed in insect microsomes using kynuramine as substrate after 20 mins by fluorescence spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Subcellular Microsome
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives.
Legoabe LJ, Petzer A, Petzer JP.
Eur J Med Chem (2012) 49 : 343 -353
PubMed 22309913 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.20 7.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1945155 1 7.02
CHEMBL1945153 1 6.97
CHEMBL1945271 1 6.76
CHEMBL1945160 1 6.59
CHEMBL1945157 1 6.49
CHEMBL1945154 1 6.41
CHEMBL1945152 1 6.37
CHEMBL1945273 1 6.32
CHEMBL1945272 1 6.06
CHEMBL1945158 1 5.95
CHEMBL1945156 1 5.91
CHEMBL1945151 1 5.72
CHEMBL1945150 1 5.51
CHEMBL323988 1 5.48
CHEMBL1945159 1 5.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1945155 IC50 = 95.0 nM 7.02
CHEMBL1945153 IC50 = 106.0 nM 6.97
CHEMBL1945271 IC50 = 175.0 nM 6.76
CHEMBL1945160 IC50 = 255.0 nM 6.59
CHEMBL1945157 IC50 = 322.0 nM 6.49
CHEMBL1945154 IC50 = 386.0 nM 6.41
CHEMBL1945152 IC50 = 424.0 nM 6.37
CHEMBL1945273 IC50 = 480.0 nM 6.32
CHEMBL1945272 IC50 = 879.0 nM 6.06
CHEMBL1945158 IC50 = 1130.0 nM 5.95
CHEMBL1945156 IC50 = 1230.0 nM 5.91
CHEMBL1945151 IC50 = 1910.0 nM 5.72
CHEMBL1945150 IC50 = 3120.0 nM 5.51
CHEMBL323988 IC50 = 3300.0 nM 5.48
CHEMBL1945159 IC50 = 3490.0 nM 5.46