Assay Detail
Functional
CHEMBL1952569
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Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of CS-0777: A Potent, Selective, and Orally Active S1P1 Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 9.20 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | -1.0 | 1 | 9.43 |
| CHEMBL1951588 | — | — | 1 | 8.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL1951588 | — | EC50 | = | 1.1 | nM | 8.96 |