Assay Detail
Binding
CHEMBL1952892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition measured after 60 mins by scintillation counting
4
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.86 | 8.15 |
| Ki | 1 | 8.21 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1950289 | TANZISERTIB | 2.0 | 2 | 8.21 |
| CHEMBL1950304 | — | — | 1 | 8.00 |
| CHEMBL1950303 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1950289 | TANZISERTIB | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL1950289 | TANZISERTIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1950304 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1950303 | — | IC50 | = | 38.0 | nM | 7.42 |