Assay Detail
Functional
CHEMBL1952995
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human K562 cells assessed as cell viability after 72 hrs by luciferase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid. 2. Impact of 3-chloro group replacement on inhibition of proliferation and induction of apoptosis of leukemia and cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.91 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176252 | — | — | 1 | 6.27 |
| CHEMBL1950943 | — | — | 1 | 6.17 |
| CHEMBL1950947 | — | — | 1 | 6.17 |
| CHEMBL1950949 | — | — | 1 | 6.17 |
| CHEMBL1950948 | — | — | 1 | 6.16 |
| CHEMBL1950946 | — | — | 1 | 5.89 |
| CHEMBL1950951 | — | — | 1 | 5.80 |
| CHEMBL1950950 | — | — | 1 | 5.79 |
| CHEMBL1950952 | — | — | 1 | 5.38 |
| CHEMBL1950944 | — | — | 1 | 5.25 |
| CHEMBL1950942 | — | — | 1 | - |
| CHEMBL1950945 | — | — | 1 | - |
| CHEMBL1950953 | — | — | 1 | - |
| CHEMBL1950954 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176252 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1950943 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1950947 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1950949 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL1950948 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1950946 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1950951 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1950950 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL1950952 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1950944 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1950942 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1950945 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1950953 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1950954 | — | IC50 | > | 5000.0 | nM | - |