Assay Detail

CHEMBL1953010

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Binding

Inhibition of mouse SCD1

ChEMBL ↗

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Target

Acyl-CoA desaturase 1 (CHEMBL5353) ↗

Open DB target context

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Acyl-CoA desaturase 1 (CHEMBL5353) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Acyl-CoA desaturase 1

CHEMBL5353

Anchored from Assay target.

Protein identity Acyl-CoA desaturase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mus musculus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Acyl-CoA desaturase 1 (CHEMBL5353) ↗

Type	SINGLE PROTEIN
Organism	Mus musculus

Publication

Nicotinic acids: liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy.

Powell DA, Black WC, Bleasby K, Chan CC, Deschenes D, Gagnon M, Gordon R, Guay J, Guiral S, Hafey MJ, Huang Z, Isabel E, Leblanc Y, Styhler A, Xu LJ, Zhang L, Oballa RM.
Bioorg Med Chem Lett (2011) 21 : 7281 -7286
PubMed 22047692 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.05	8.05

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1950397	—	—	1	8.05

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1950397	—	IC50	=	9.0	nM	8.05