Assay Detail
Binding
CHEMBL1954565
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Inhibition of FLT3
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.62 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1952126 | — | — | 1 | 7.92 |
| CHEMBL1952136 | — | — | 1 | 7.55 |
| CHEMBL1952141 | — | — | 1 | 7.36 |
| CHEMBL1952144 | — | — | 1 | 6.90 |
| CHEMBL1952113 | — | — | 1 | 6.64 |
| CHEMBL1952137 | — | — | 1 | 6.50 |
| CHEMBL1952125 | — | — | 1 | 6.11 |
| CHEMBL1952142 | — | — | 1 | 5.40 |
| CHEMBL1952143 | — | — | 1 | 5.16 |
| CHEMBL1952121 | — | — | 1 | - |
| CHEMBL1952132 | — | — | 1 | - |
| CHEMBL1952133 | — | — | 1 | - |
| CHEMBL1952134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1952126 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1952136 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1952141 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1952144 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL1952113 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL1952137 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL1952125 | — | IC50 | = | 778.0 | nM | 6.11 |
| CHEMBL1952142 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1952143 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1952121 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1952132 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1952133 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1952134 | — | IC50 | > | 1000.0 | nM | - |