Assay Detail
Functional
CHEMBL1954853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.23 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 8.41 |
| CHEMBL1950598 | — | — | 1 | 7.00 |
| CHEMBL1950592 | — | — | 1 | 6.96 |
| CHEMBL25948 | SHOGAOL | — | 1 | 6.50 |
| CHEMBL1950597 | — | — | 1 | 6.30 |
| CHEMBL1097449 | — | — | 1 | 6.00 |
| CHEMBL1950586 | — | — | 1 | 5.92 |
| CHEMBL1950582 | — | — | 1 | 5.48 |
| CHEMBL1950596 | — | — | 1 | 4.84 |
| CHEMBL1950588 | — | — | 1 | 4.84 |
| CHEMBL1950583 | — | — | 1 | - |
| CHEMBL1950584 | — | — | 1 | - |
| CHEMBL1950585 | — | — | 1 | - |
| CHEMBL1950587 | — | — | 1 | - |
| CHEMBL1950589 | — | — | 1 | - |
| CHEMBL1950590 | — | — | 1 | - |
| CHEMBL487732 | — | — | 1 | - |
| CHEMBL1950591 | — | — | 1 | - |
| CHEMBL1950595 | — | — | 1 | - |
| CHEMBL1950593 | — | — | 1 | - |
| CHEMBL1950594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1950598 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1950592 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL25948 | SHOGAOL | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1950597 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1097449 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1950586 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1950582 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1950596 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL1950588 | — | EC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1950583 | — | EC50 | - | — | - | |
| CHEMBL1950584 | — | EC50 | - | — | - | |
| CHEMBL1950585 | — | EC50 | - | — | - | |
| CHEMBL1950587 | — | EC50 | - | — | - | |
| CHEMBL1950589 | — | EC50 | - | — | - | |
| CHEMBL1950590 | — | EC50 | - | — | - | |
| CHEMBL487732 | — | EC50 | - | — | - | |
| CHEMBL1950591 | — | EC50 | - | — | - | |
| CHEMBL1950595 | — | EC50 | - | — | - | |
| CHEMBL1950593 | — | EC50 | - | — | - | |
| CHEMBL1950594 | — | EC50 | - | — | - |