Assay Detail
Functional
CHEMBL1954858
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily A member 1 (CHEMBL5160) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.94 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1950598 | — | — | 1 | 5.64 |
| CHEMBL1950584 | — | — | 1 | 5.55 |
| CHEMBL1950593 | — | — | 1 | 5.55 |
| CHEMBL1950590 | — | — | 1 | 5.48 |
| CHEMBL1950595 | — | — | 1 | 5.44 |
| CHEMBL1950587 | — | — | 1 | 5.41 |
| CHEMBL487732 | — | — | 1 | 5.35 |
| CHEMBL1950594 | — | — | 1 | 4.96 |
| CHEMBL1950597 | — | — | 1 | 4.84 |
| CHEMBL1950589 | — | — | 1 | 4.84 |
| CHEMBL1950596 | — | — | 1 | 4.80 |
| CHEMBL25948 | SHOGAOL | — | 1 | 4.78 |
| CHEMBL1950586 | — | — | 1 | 4.65 |
| CHEMBL1097449 | — | — | 1 | 4.46 |
| CHEMBL1950592 | — | — | 1 | 4.42 |
| CHEMBL1950591 | — | — | 1 | 4.40 |
| CHEMBL1950585 | — | — | 1 | 4.25 |
| CHEMBL1950588 | — | — | 1 | 4.01 |
| CHEMBL1950582 | — | — | 1 | - |
| CHEMBL1950583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1950598 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL1950584 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1950593 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1950590 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1950595 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1950587 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL487732 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1950594 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL1950597 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL1950589 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1950596 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL25948 | SHOGAOL | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL1950586 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL1097449 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL1950592 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL1950591 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL1950585 | — | IC50 | = | 56100.0 | nM | 4.25 |
| CHEMBL1950588 | — | IC50 | = | 97850.0 | nM | 4.01 |
| CHEMBL1950582 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1950583 | — | IC50 | > | 100000.0 | nM | - |