Assay Detail
Functional
CHEMBL1955237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat P2Y purinoceptor 6 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry
15
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Boranophosphate isoster controls P2Y-receptor subtype selectivity and metabolic stability of dinucleoside polyphosphate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.65 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 6.70 |
| CHEMBL2029008 | — | — | 2 | 6.52 |
| CHEMBL2029004 | — | — | 2 | 6.01 |
| CHEMBL2029005 | — | — | 2 | 5.89 |
| CHEMBL2029010 | — | — | 2 | 5.41 |
| CHEMBL2029006 | — | — | 2 | 4.93 |
| CHEMBL2029007 | — | — | 2 | - |
| CHEMBL2029009 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2029008 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2029008 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2029004 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL2029005 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2029005 | — | EC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL2029004 | — | EC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL2029010 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL2029006 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL2029006 | — | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL2029010 | — | EC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL2029007 | — | EC50 | - | — | - | |
| CHEMBL2029007 | — | EC50 | - | — | - | |
| CHEMBL2029009 | — | EC50 | - | — | - | |
| CHEMBL2029009 | — | EC50 | - | — | - |