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Assay Detail

CHEMBL1955704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani S1 promastigotes after 72 hrs by alamar blue assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Caminos AP, Panozzo-Zenere EA, Wilkinson SR, Tekwani BL, Labadie GR.
Bioorg Med Chem Lett (2012) 22 : 1712 -1715
PubMed 22248858 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 5.74 7.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL280180 1 7.51
CHEMBL1950477 1 6.68
CHEMBL1950478 1 6.66
CHEMBL1950475 1 6.64
CHEMBL1950476 1 6.62
CHEMBL1950467 1 6.62
CHEMBL1950466 1 6.58
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.50
CHEMBL1950468 1 5.94
CHEMBL1950479 1 5.92
CHEMBL1950462 1 5.91
CHEMBL1950465 1 5.84
CHEMBL1950464 1 5.81
CHEMBL1950461 1 5.76
CHEMBL1950474 1 5.35
CHEMBL1950469 1 5.34
CHEMBL55 PENTAMIDINE 4.0 1 5.21
CHEMBL1950463 1 5.17
CHEMBL23440 1 5.07
CHEMBL1950460 1 4.99
CHEMBL1950459 1 4.96
CHEMBL197209 1 4.86
CHEMBL277864 1 4.73
CHEMBL1950472 1 4.36
CHEMBL1950473 1 4.35
CHEMBL1950471 1 -
CHEMBL1950470 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL280180 IC50 = 31.0 nM 7.51
CHEMBL1950477 IC50 = 210.0 nM 6.68
CHEMBL1950478 IC50 = 220.0 nM 6.66
CHEMBL1950475 IC50 = 230.0 nM 6.64
CHEMBL1950476 IC50 = 240.0 nM 6.62
CHEMBL1950467 IC50 = 240.0 nM 6.62
CHEMBL1950466 IC50 = 260.0 nM 6.58
CHEMBL267345 AMPHOTERICIN B IC50 = 320.0 nM 6.50
CHEMBL1950468 IC50 = 1140.0 nM 5.94
CHEMBL1950479 IC50 = 1200.0 nM 5.92
CHEMBL1950462 IC50 = 1240.0 nM 5.91
CHEMBL1950465 IC50 = 1450.0 nM 5.84
CHEMBL1950464 IC50 = 1560.0 nM 5.81
CHEMBL1950461 IC50 = 1750.0 nM 5.76
CHEMBL1950474 IC50 = 4500.0 nM 5.35
CHEMBL1950469 IC50 = 4600.0 nM 5.34
CHEMBL55 PENTAMIDINE IC50 = 6200.0 nM 5.21
CHEMBL1950463 IC50 = 6730.0 nM 5.17
CHEMBL23440 IC50 = 8520.0 nM 5.07
CHEMBL1950460 IC50 = 10170.0 nM 4.99
CHEMBL1950459 IC50 = 11010.0 nM 4.96
CHEMBL197209 IC50 = 13830.0 nM 4.86
CHEMBL277864 IC50 = 18630.0 nM 4.73
CHEMBL1950472 IC50 = 43760.0 nM 4.36
CHEMBL1950473 IC50 = 44410.0 nM 4.35
CHEMBL1950471 IC50 > 100000.0 nM -
CHEMBL1950470 IC50 > 100000.0 nM -