Assay Detail
Binding
CHEMBL1958525
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Inhibition of human aromatase coexpressed with P450 reductase by fluorimetry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New aromatase inhibitors from the 3-pyridyl arylether and 1-aryl pyrrolo[2,3-c]pyridine series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.75 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 9.00 |
| CHEMBL1956186 | — | — | 1 | 7.23 |
| CHEMBL1955869 | — | — | 1 | 7.03 |
| CHEMBL1956188 | — | — | 1 | 6.94 |
| CHEMBL1956180 | — | — | 1 | 6.64 |
| CHEMBL1956171 | — | — | 1 | 6.54 |
| CHEMBL1956179 | — | — | 1 | 6.52 |
| CHEMBL1956183 | — | — | 1 | 6.28 |
| CHEMBL1956175 | — | — | 1 | 6.01 |
| CHEMBL1728910 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1956186 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL1955869 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1956188 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1956180 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL1956171 | — | IC50 | = | 289.0 | nM | 6.54 |
| CHEMBL1956179 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL1956183 | — | IC50 | = | 523.0 | nM | 6.28 |
| CHEMBL1956175 | — | IC50 | = | 986.0 | nM | 6.01 |
| CHEMBL1728910 | — | IC50 | = | 5030.0 | nM | 5.30 |