Assay Detail
Binding
CHEMBL1959154
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Inhibition of ribonuclease H activity of HIV1 reverse transcriptase using as poly(dC)-[3H]poly(rG) as substrate
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 4.43 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958265 | — | — | 1 | 5.70 |
| CHEMBL1958254 | — | — | 1 | 5.08 |
| CHEMBL565153 | — | — | 1 | 5.00 |
| CHEMBL1958255 | — | — | 1 | 4.82 |
| CHEMBL1958231 | — | — | 1 | 4.80 |
| CHEMBL1958456 | — | — | 1 | 4.75 |
| CHEMBL1408276 | — | — | 1 | 4.75 |
| CHEMBL1958256 | — | — | 1 | 4.68 |
| CHEMBL1958232 | — | — | 1 | 4.68 |
| CHEMBL1958233 | — | — | 1 | 4.68 |
| CHEMBL1958257 | — | — | 1 | 4.66 |
| CHEMBL1958234 | — | — | 1 | 4.30 |
| CHEMBL1958258 | — | — | 1 | 4.29 |
| CHEMBL1958259 | — | — | 1 | 4.26 |
| CHEMBL1958235 | — | — | 1 | 4.24 |
| CHEMBL1958236 | — | — | 1 | 4.21 |
| CHEMBL1958260 | — | — | 1 | 4.21 |
| CHEMBL1955890 | — | — | 1 | 4.20 |
| CHEMBL1958237 | — | — | 1 | 4.19 |
| CHEMBL1958451 | — | — | 1 | 4.12 |
| CHEMBL1958261 | — | — | 1 | 4.05 |
| CHEMBL1958443 | — | — | 1 | 4.02 |
| CHEMBL1716365 | — | — | 1 | 4.01 |
| CHEMBL1958457 | — | — | 1 | 4.00 |
| CHEMBL1958445 | — | — | 1 | 4.00 |
| CHEMBL1958446 | — | — | 1 | 4.00 |
| CHEMBL1958262 | — | — | 1 | 4.00 |
| CHEMBL1958450 | — | — | 1 | - |
| CHEMBL1958444 | — | — | 1 | - |
| CHEMBL345460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958265 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1958254 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL565153 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1958255 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1958231 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1958456 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1408276 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1958256 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1958232 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1958233 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL1958257 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1958234 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1958258 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1958259 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1958235 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL1958236 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL1958260 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL1955890 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL1958237 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1958451 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1958261 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL1958443 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL1716365 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL1958262 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1958446 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1958457 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1958445 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1958246 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958245 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958244 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958242 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1888144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1955892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958458 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1361764 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958454 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958453 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958441 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958459 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958449 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958448 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345460 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958450 | — | IC50 | > | 100000.0 | nM | - |