Assay Detail
Binding
CHEMBL1959233
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Inhibition of RNA-dependent DNA polymerase activity of Human immunodeficiency virus 1 reverse transcriptase
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 4.56 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958457 | — | — | 1 | 6.00 |
| CHEMBL1958265 | — | — | 1 | 5.85 |
| CHEMBL1958234 | — | — | 1 | 5.05 |
| CHEMBL565153 | — | — | 1 | 5.00 |
| CHEMBL1958254 | — | — | 1 | 4.95 |
| CHEMBL1716365 | — | — | 1 | 4.80 |
| CHEMBL1958258 | — | — | 1 | 4.72 |
| CHEMBL1958231 | — | — | 1 | 4.66 |
| CHEMBL1958255 | — | — | 1 | 4.60 |
| CHEMBL1958256 | — | — | 1 | 4.55 |
| CHEMBL1958456 | — | — | 1 | 4.54 |
| CHEMBL1958448 | — | — | 1 | 4.43 |
| CHEMBL1955890 | — | — | 1 | 4.36 |
| CHEMBL1958459 | — | — | 1 | 4.29 |
| CHEMBL1958443 | — | — | 1 | 4.23 |
| CHEMBL1958447 | — | — | 1 | 4.18 |
| CHEMBL1958260 | — | — | 1 | 4.17 |
| CHEMBL1958257 | — | — | 1 | 4.16 |
| CHEMBL1958451 | — | — | 1 | 4.14 |
| CHEMBL1958263 | — | — | 1 | 4.11 |
| CHEMBL1958259 | — | — | 1 | 4.08 |
| CHEMBL1958458 | — | — | 1 | 4.07 |
| CHEMBL1958261 | — | — | 1 | 4.00 |
| CHEMBL1958441 | — | — | 1 | - |
| CHEMBL1408276 | — | — | 1 | - |
| CHEMBL1958442 | — | — | 1 | - |
| CHEMBL1958453 | — | — | 1 | - |
| CHEMBL1958454 | — | — | 1 | - |
| CHEMBL1361764 | — | — | 1 | - |
| CHEMBL1958455 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958457 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1958265 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1958234 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL565153 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1958254 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL1716365 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1958258 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1958231 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1958255 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1958256 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1958456 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1958448 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL1955890 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL1958459 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL1958443 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1958447 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL1958260 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL1958257 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL1958451 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL1958263 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL1958259 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL1958458 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL1958261 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL1958237 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958262 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958236 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958446 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345460 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958235 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958449 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958450 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1888144 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1955892 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958232 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958233 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958455 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1361764 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958454 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958453 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958442 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1408276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1958441 | — | IC50 | > | 100000.0 | nM | - |