Assay Detail
Binding
CHEMBL1959296
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Inhibition of VEGFR2
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1095464 | — | — | 1 | 6.60 |
| CHEMBL1095465 | — | — | 1 | 6.21 |
| CHEMBL474538 | — | — | 1 | 5.29 |
| CHEMBL499345 | — | — | 1 | 5.25 |
| CHEMBL1956887 | — | — | 1 | 5.22 |
| CHEMBL1956885 | — | — | 1 | 5.08 |
| CHEMBL514014 | — | — | 1 | 5.03 |
| CHEMBL1095761 | — | — | 1 | 4.55 |
| CHEMBL502015 | — | — | 1 | - |
| CHEMBL1956886 | — | — | 1 | - |
| CHEMBL499344 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1095464 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1095465 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL474538 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL499345 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL1956887 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL1956885 | — | IC50 | = | 8280.0 | nM | 5.08 |
| CHEMBL514014 | — | IC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL1095761 | — | IC50 | = | 28110.0 | nM | 4.55 |
| CHEMBL502015 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1956886 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL499344 | — | IC50 | > | 50000.0 | nM | - |