Assay Detail
Binding
CHEMBL1959441
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Inhibition of HDAC2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.23 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.75 |
| CHEMBL251819 | — | — | 1 | 6.33 |
| CHEMBL1957458 | — | — | 1 | 6.17 |
| CHEMBL1957463 | — | — | 1 | 6.13 |
| CHEMBL1957459 | — | — | 1 | 6.10 |
| CHEMBL1957464 | — | — | 1 | 6.06 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.82 |
| CHEMBL407420 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL251819 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1957458 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1957463 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL1957459 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1957464 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL407420 | — | IC50 | = | 3360.0 | nM | 5.47 |