Assay Detail
Binding
CHEMBL1959673
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Inhibition of HCV1b NS3/4A protease
21
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GS-9256: a novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.19 | 9.00 |
| Ki | 1 | 10.05 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956820 | GS-9256 | 2.0 | 2 | 10.05 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 9.00 |
| CHEMBL1956822 | — | — | 1 | 8.52 |
| CHEMBL1956809 | — | — | 1 | 8.40 |
| CHEMBL1956819 | — | — | 1 | 8.40 |
| CHEMBL1956815 | — | — | 1 | 8.40 |
| CHEMBL1779118 | — | — | 1 | 8.22 |
| CHEMBL1779116 | — | — | 1 | 8.22 |
| CHEMBL1956818 | — | — | 1 | 8.22 |
| CHEMBL1956817 | — | — | 1 | 8.22 |
| CHEMBL1779114 | — | — | 1 | 8.15 |
| CHEMBL1956811 | — | — | 1 | 8.15 |
| CHEMBL1956812 | — | — | 1 | 8.15 |
| CHEMBL1956808 | — | — | 1 | 8.10 |
| CHEMBL1956807 | — | — | 1 | 8.10 |
| CHEMBL1956810 | — | — | 1 | 8.10 |
| CHEMBL1956813 | — | — | 1 | 8.00 |
| CHEMBL1956821 | — | — | 1 | 7.96 |
| CHEMBL1956814 | — | — | 1 | 7.82 |
| CHEMBL1956816 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956820 | GS-9256 | Ki | = | 0.089 | nM | 10.05 |
| CHEMBL297884 | CILUPREVIR | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1956822 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1956809 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956820 | GS-9256 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956819 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956815 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1956817 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1956818 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1779116 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1779118 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1779114 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1956812 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1956811 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1956808 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1956807 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1956810 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1956813 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1956821 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1956814 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1956816 | — | IC50 | = | 63.0 | nM | 7.20 |