Assay Detail
Binding
CHEMBL1959709
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Displacement of [3H]2-BFI from Sprague-Dawley rat I2 imidazoline binding site by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.12 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956902 | — | — | 1 | 6.52 |
| CHEMBL1956900 | — | — | 1 | 6.35 |
| CHEMBL1956901 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956902 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL1956900 | — | Ki | = | 446.68 | nM | 6.35 |
| CHEMBL1956901 | — | Ki | = | 3311.31 | nM | 5.48 |