Assay Detail
Binding
CHEMBL1960054
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Inhibition of HIV1 reverse transcriptase assessed as incorporation of biotin-dUTP into poly(rA)-oligo(dT)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.78 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 6.26 |
| CHEMBL1957900 | — | — | 1 | 5.75 |
| CHEMBL1957773 | — | — | 1 | 5.71 |
| CHEMBL1957769 | — | — | 1 | 5.61 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1957900 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL1957773 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL1957769 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 2740.0 | nM | 5.56 |