Assay Detail
Binding
CHEMBL1960215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrate mix after 30 mins by microplate reader
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.80 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957366 | — | — | 1 | 6.70 |
| CHEMBL1957462 | — | — | 1 | 5.96 |
| CHEMBL1957460 | — | — | 1 | 5.89 |
| CHEMBL1957380 | — | — | 1 | 5.24 |
| CHEMBL1957370 | — | — | 1 | 5.20 |
| CHEMBL1957379 | — | — | 1 | - |
| CHEMBL1957381 | — | — | 1 | - |
| CHEMBL1957372 | — | — | 1 | - |
| CHEMBL1957371 | — | — | 1 | - |
| CHEMBL1957461 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957366 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1957462 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1957460 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1957380 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1957370 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1957379 | — | IC50 | > | 9900.0 | nM | - |
| CHEMBL1957381 | — | IC50 | > | 9900.0 | nM | - |
| CHEMBL1957372 | — | IC50 | > | 9900.0 | nM | - |
| CHEMBL1957371 | — | IC50 | > | 9900.0 | nM | - |
| CHEMBL1957461 | — | IC50 | > | 9900.0 | nM | - |