Assay Detail
Binding
CHEMBL1960313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of extracellular matrix protein fibrinogen from human integrin alpha2bbeta3 after 1 hr by competitive ELISA
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.78 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59562 | — | — | 1 | 9.09 |
| CHEMBL916 | TIROFIBAN | 4.0 | 1 | 9.02 |
| CHEMBL1956150 | — | — | 1 | 8.92 |
| CHEMBL1956154 | — | — | 1 | 8.48 |
| CHEMBL1956158 | — | — | 1 | 8.36 |
| CHEMBL1956151 | — | — | 1 | 8.20 |
| CHEMBL1956152 | — | — | 1 | 7.64 |
| CHEMBL1956156 | — | — | 1 | 7.20 |
| CHEMBL1956153 | — | — | 1 | 6.87 |
| CHEMBL1956155 | — | — | 1 | 5.94 |
| CHEMBL1956157 | — | — | 1 | 5.88 |
| CHEMBL1956160 | — | — | 1 | - |
| CHEMBL1956159 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59562 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL916 | TIROFIBAN | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL1956150 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1956154 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1956158 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1956151 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL1956152 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL1956156 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL1956153 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL1956155 | — | IC50 | = | 1154.0 | nM | 5.94 |
| CHEMBL1956157 | — | IC50 | = | 1322.0 | nM | 5.88 |
| CHEMBL1956160 | — | IC50 | - | — | - | |
| CHEMBL1956159 | — | IC50 | - | — | - |