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Assay Detail

CHEMBL1960329

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antifungal activity against Trichophyton mentagrophytes IBT 2724 after 7 days by micro broth dilution method
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trichophyton mentagrophytes
Confidence 1 — Organism
Curated By Autocuration

Target

Trichophyton mentagrophytes (CHEMBL613162)
Type ORGANISM
Organism Trichophyton mentagrophytes

Publication

Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
Rønnest MH, Raab MS, Anderhub S, Boesen S, Krämer A, Larsen TO, Clausen MH.
J Med Chem (2012) 55 : 652 -660
PubMed 22191585 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 6.61 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1956511 1 7.39
CHEMBL522763 1 7.30
CHEMBL491938 1 7.24
CHEMBL562 GRISEOFULVIN 4.0 1 7.24
CHEMBL491757 1 7.22
CHEMBL1956508 1 7.21
CHEMBL489537 1 6.96
CHEMBL1956519 1 6.85
CHEMBL1956512 1 6.82
CHEMBL1956345 1 6.77
CHEMBL490124 1 6.72
CHEMBL490548 1 6.64
CHEMBL491114 1 6.62
CHEMBL490921 1 6.62
CHEMBL1956514 1 6.60
CHEMBL522427 1 6.60
CHEMBL489536 1 6.60
CHEMBL521969 1 6.58
CHEMBL492106 1 6.55
CHEMBL489517 1 6.54
CHEMBL522298 1 6.52
CHEMBL1956516 1 6.46
CHEMBL1956518 1 6.16
CHEMBL490710 1 5.96
CHEMBL1956515 1 5.89
CHEMBL523820 1 5.80
CHEMBL1956513 1 5.77
CHEMBL491968 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1956511 IC50 = 41.0 nM 7.39
CHEMBL522763 IC50 = 50.0 nM 7.30
CHEMBL491938 IC50 = 58.0 nM 7.24
CHEMBL562 GRISEOFULVIN IC50 = 58.0 nM 7.24
CHEMBL491757 IC50 = 60.0 nM 7.22
CHEMBL1956508 IC50 = 62.0 nM 7.21
CHEMBL489537 IC50 = 110.0 nM 6.96
CHEMBL1956519 IC50 = 140.0 nM 6.85
CHEMBL1956512 IC50 = 150.0 nM 6.82
CHEMBL1956345 IC50 = 170.0 nM 6.77
CHEMBL490124 IC50 = 190.0 nM 6.72
CHEMBL490548 IC50 = 230.0 nM 6.64
CHEMBL491114 IC50 = 240.0 nM 6.62
CHEMBL490921 IC50 = 240.0 nM 6.62
CHEMBL1956514 IC50 = 250.0 nM 6.60
CHEMBL522427 IC50 = 250.0 nM 6.60
CHEMBL489536 IC50 = 250.0 nM 6.60
CHEMBL521969 IC50 = 260.0 nM 6.58
CHEMBL492106 IC50 = 280.0 nM 6.55
CHEMBL489517 IC50 = 290.0 nM 6.54
CHEMBL522298 IC50 = 300.0 nM 6.52
CHEMBL1956516 IC50 = 350.0 nM 6.46
CHEMBL1956518 IC50 = 700.0 nM 6.16
CHEMBL490710 IC50 = 1100.0 nM 5.96
CHEMBL1956515 IC50 = 1300.0 nM 5.89
CHEMBL523820 IC50 = 1600.0 nM 5.80
CHEMBL1956513 IC50 = 1700.0 nM 5.77
CHEMBL491968 IC50 = 3000.0 nM 5.52