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Assay Detail

CHEMBL1960403

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human IMR32 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type IMR-32
Confidence 1 — Organism
Curated By Autocuration

Target

IMR-32 (CHEMBL614585)
Type CELL-LINE
Organism Homo sapiens

Publication

Catalysis by molecular iodine: a rapid synthesis of 1,8-dioxo-octahydroxanthenes and their evaluation as potential anticancer agents.
Mulakayala N, Murthy PV, Rambabu D, Aeluri M, Adepu R, Krishna GR, Reddy CM, Prasad KR, Chaitanya M, Kumar CS, Rao MV, Pal M.
Bioorg Med Chem Lett (2012) 22 : 2186 -2191
PubMed 22365759 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.34 4.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1956449 1 4.64
CHEMBL1956460 1 4.46
CHEMBL269538 HARMINE 1.0 1 4.42
CHEMBL1604546 1 4.39
CHEMBL1956446 1 4.38
CHEMBL1956459 1 4.38
CHEMBL1956457 1 4.35
CHEMBL1348027 1 4.35
CHEMBL1956453 1 4.34
CHEMBL1956450 1 4.31
CHEMBL1956448 1 4.31
CHEMBL1956452 1 4.28
CHEMBL1956455 1 4.28
CHEMBL1956447 1 4.26
CHEMBL1956458 1 4.25
CHEMBL1956451 1 4.21
CHEMBL1956456 1 4.20
CHEMBL1956454 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1956449 IC50 = 23000.0 nM 4.64
CHEMBL1956460 IC50 = 35000.0 nM 4.46
CHEMBL269538 HARMINE IC50 = 38000.0 nM 4.42
CHEMBL1604546 IC50 = 41000.0 nM 4.39
CHEMBL1956446 IC50 = 42000.0 nM 4.38
CHEMBL1956459 IC50 = 42000.0 nM 4.38
CHEMBL1956457 IC50 = 45000.0 nM 4.35
CHEMBL1348027 IC50 = 45000.0 nM 4.35
CHEMBL1956453 IC50 = 46000.0 nM 4.34
CHEMBL1956450 IC50 = 49000.0 nM 4.31
CHEMBL1956448 IC50 = 49000.0 nM 4.31
CHEMBL1956452 IC50 = 53000.0 nM 4.28
CHEMBL1956455 IC50 = 52000.0 nM 4.28
CHEMBL1956447 IC50 = 55000.0 nM 4.26
CHEMBL1956458 IC50 = 56000.0 nM 4.25
CHEMBL1956451 IC50 = 62000.0 nM 4.21
CHEMBL1956456 IC50 = 63000.0 nM 4.20
CHEMBL1956454 IC50 > 100000.0 nM -