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Assay Detail

CHEMBL1960494

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to VAchT
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Vesicular acetylcholine transporter (CHEMBL4767)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrrolovesamicols--synthesis, structure and VAChT binding of two 4-fluorobenzoyl regioisomers.
Wenzel B, Li Y, Kraus W, Sorger D, Sabri O, Brust P, Steinbach J.
Bioorg Med Chem Lett (2012) 22 : 2163 -2166
PubMed 22365760 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 9.43 9.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1956465 1 9.49
CHEMBL1956464 1 9.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1956465 Ki = 0.32 nM 9.49
CHEMBL1956464 Ki = 0.44 nM 9.36