Assay Detail
Binding
CHEMBL1960508
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Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.29 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956579 | — | — | 1 | 7.80 |
| CHEMBL186422 | — | — | 1 | 7.44 |
| CHEMBL1956578 | — | — | 1 | 7.32 |
| CHEMBL1200471 | PYRITHIONE ZINC | 4.0 | 1 | 5.54 |
| CHEMBL251680 | COUMAPHOS | 2.0 | 1 | 5.38 |
| CHEMBL1955873 | THIOBENZOIC ACID | — | 1 | 5.34 |
| CHEMBL508338 | THIMEROSAL | 3.0 | 1 | 5.18 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956579 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL186422 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL1956578 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL1200471 | PYRITHIONE ZINC | Ki | = | 2910.0 | nM | 5.54 |
| CHEMBL251680 | COUMAPHOS | Ki | = | 4140.0 | nM | 5.38 |
| CHEMBL1955873 | THIOBENZOIC ACID | Ki | = | 4550.0 | nM | 5.34 |
| CHEMBL508338 | THIMEROSAL | Ki | = | 6580.0 | nM | 5.18 |
| CHEMBL6466 | COUMARIN | Ki | > | 200000.0 | nM | - |