Assay Detail
Binding
CHEMBL1960758
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Inhibition of HDAC expressed in human HeLa cells after 1 hr by fluorescence analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.31 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1958429 | — | — | 1 | 8.00 |
| CHEMBL1958439 | — | — | 1 | 7.89 |
| CHEMBL453755 | — | — | 1 | 7.70 |
| CHEMBL1958436 | — | — | 1 | 7.70 |
| CHEMBL1958433 | — | — | 1 | 7.66 |
| CHEMBL1958434 | — | — | 1 | 7.66 |
| CHEMBL1958437 | — | — | 1 | 7.66 |
| CHEMBL272847 | — | — | 1 | 7.64 |
| CHEMBL490018 | — | — | 1 | 7.58 |
| CHEMBL1958430 | — | — | 1 | 7.55 |
| CHEMBL1955942 | — | — | 1 | 7.54 |
| CHEMBL1958438 | — | — | 1 | 7.38 |
| CHEMBL1958440 | — | — | 1 | 7.32 |
| CHEMBL1958428 | — | — | 1 | 7.17 |
| CHEMBL1958422 | — | — | 1 | 7.08 |
| CHEMBL1958424 | — | — | 1 | 6.91 |
| CHEMBL1958432 | — | — | 1 | 6.88 |
| CHEMBL1958423 | — | — | 1 | 6.83 |
| CHEMBL1958425 | — | — | 1 | 6.73 |
| CHEMBL1958427 | — | — | 1 | 6.72 |
| CHEMBL1958431 | — | — | 1 | 6.67 |
| CHEMBL1958435 | — | — | 1 | 6.57 |
| CHEMBL1958426 | — | — | 1 | - |
| CHEMBL1955943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1958429 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1958439 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL453755 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1958436 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1958433 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1958434 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL1958437 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL272847 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL490018 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1958430 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1955942 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1958438 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1958440 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL1958428 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1958422 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1958424 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL1958432 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1958423 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL1958425 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL1958427 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL1958431 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL1958435 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL1958426 | — | IC50 | - | — | - | |
| CHEMBL1955943 | — | IC50 | - | — | - |