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Assay Detail

CHEMBL1960832

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PANC1 cells after 48 hrs by WST-8 assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PANC-1
Confidence 1 — Organism
Curated By Autocuration

Target

PANC-1 (CHEMBL614139)
Type CELL-LINE
Organism Homo sapiens

Publication

One pot synthesis and anticancer activity of dimeric phloroglucinols.
Chauthe SK, Bharate SB, Periyasamy G, Khanna A, Bhutani KK, Mishra PD, Singh IP.
Bioorg Med Chem Lett (2012) 22 : 2251 -2256
PubMed 22342146 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.24 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 6.96
CHEMBL1956703 1 5.21
CHEMBL591222 1 5.14
CHEMBL1956696 1 5.08
CHEMBL225249 1 5.07
CHEMBL1956694 1 5.07
CHEMBL1956708 1 5.06
CHEMBL1956697 1 5.04
CHEMBL1956693 1 5.03
CHEMBL1956705 1 5.02
CHEMBL1956702 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 110.0 nM 6.96
CHEMBL1956703 IC50 = 6100.0 nM 5.21
CHEMBL591222 IC50 = 7200.0 nM 5.14
CHEMBL1956696 IC50 = 8300.0 nM 5.08
CHEMBL225249 IC50 = 8500.0 nM 5.07
CHEMBL1956694 IC50 = 8500.0 nM 5.07
CHEMBL1956708 IC50 = 8800.0 nM 5.06
CHEMBL1956697 IC50 = 9100.0 nM 5.04
CHEMBL1956693 IC50 = 9400.0 nM 5.03
CHEMBL1956705 IC50 = 9600.0 nM 5.02
CHEMBL1956702 IC50 = 9800.0 nM 5.01