Assay Detail
Functional
CHEMBL1960893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat EP2 receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP2 subtype (CHEMBL4909) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.57 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | 4.0 | 1 | 7.72 |
| CHEMBL1933722 | — | — | 1 | 7.05 |
| CHEMBL1957436 | — | — | 1 | 6.58 |
| CHEMBL222715 | — | — | 1 | 5.75 |
| CHEMBL1957435 | — | — | 1 | 5.75 |
| CHEMBL42027 | — | — | 1 | - |
| CHEMBL223151 | — | — | 1 | - |
| CHEMBL1957437 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL548 | DINOPROSTONE | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1933722 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1957436 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL222715 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1957435 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL42027 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL223151 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL1957437 | — | EC50 | > | 10000.0 | nM | - |