Assay Detail
Functional
CHEMBL1961022
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Antitumor activity against human SKOV3 cells co-cultured with mesothelial cell monolayers by firefly luciferase reporter gene assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.98 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270299 | BAY-11-7085 | — | 1 | 5.12 |
| CHEMBL1958376 | — | — | 1 | 5.00 |
| CHEMBL1958390 | — | — | 1 | 4.96 |
| CHEMBL1958388 | — | — | 1 | 4.94 |
| CHEMBL1958389 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270299 | BAY-11-7085 | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1958376 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1958390 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL1958388 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1958389 | — | IC50 | = | 12900.0 | nM | 4.89 |