Assay Detail
Binding
CHEMBL1961098
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay
83
Total Activities
83
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL1966) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 83 | 4.39 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1956291 | — | — | 1 | 4.39 |
| CHEMBL1956293 | — | — | 1 | - |
| CHEMBL1956269 | — | — | 1 | - |
| CHEMBL1956268 | — | — | 1 | - |
| CHEMBL1956267 | — | — | 1 | - |
| CHEMBL1956266 | — | — | 1 | - |
| CHEMBL1956265 | — | — | 1 | - |
| CHEMBL1956264 | — | — | 1 | - |
| CHEMBL1956263 | — | — | 1 | - |
| CHEMBL1956262 | — | — | 1 | - |
| CHEMBL1956270 | — | — | 1 | - |
| CHEMBL1956298 | — | — | 1 | - |
| CHEMBL1956297 | — | — | 1 | - |
| CHEMBL1956296 | — | — | 1 | - |
| CHEMBL1956295 | — | — | 1 | - |
| CHEMBL1956294 | — | — | 1 | - |
| CHEMBL1956292 | — | — | 1 | - |
| CHEMBL1956290 | — | — | 1 | - |
| CHEMBL1956280 | — | — | 1 | - |
| CHEMBL1956288 | — | — | 1 | - |
| CHEMBL1956287 | — | — | 1 | - |
| CHEMBL1956286 | — | — | 1 | - |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | - |
| CHEMBL1738786 | — | — | 1 | - |
| CHEMBL1956284 | — | — | 1 | - |
| CHEMBL1956283 | — | — | 1 | - |
| CHEMBL1956282 | — | — | 1 | - |
| CHEMBL1956281 | — | — | 1 | - |
| CHEMBL1955870 | — | — | 1 | - |
| CHEMBL1956289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1956291 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1956275 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956266 | — | IC50 | - | — | - | |
| CHEMBL1956267 | — | IC50 | - | — | - | |
| CHEMBL1956268 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956269 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956260 | — | IC50 | - | — | - | |
| CHEMBL1956261 | — | IC50 | - | — | - | |
| CHEMBL1956299 | — | IC50 | - | — | - | |
| CHEMBL1956271 | — | IC50 | - | — | - | |
| CHEMBL1956272 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956273 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956274 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956265 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956277 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956279 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956489 | — | IC50 | - | — | - | |
| CHEMBL1956479 | — | IC50 | - | — | - | |
| CHEMBL1956480 | — | IC50 | - | — | - | |
| CHEMBL1956481 | — | IC50 | - | — | - | |
| CHEMBL1956482 | — | IC50 | - | — | - | |
| CHEMBL1956483 | — | IC50 | - | — | - | |
| CHEMBL1956484 | — | IC50 | - | — | - | |
| CHEMBL1956485 | — | IC50 | - | — | - | |
| CHEMBL1956280 | — | IC50 | - | — | - | |
| CHEMBL1956289 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1955870 | — | IC50 | - | — | - | |
| CHEMBL1956281 | — | IC50 | - | — | - | |
| CHEMBL1956282 | — | IC50 | - | — | - | |
| CHEMBL1956283 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956284 | — | IC50 | - | — | - | |
| CHEMBL1738786 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956285 | DSM-265 | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956287 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956288 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956290 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1956292 | — | IC50 | - | — | - | |
| CHEMBL1956293 | — | IC50 | - | — | - | |
| CHEMBL1956294 | — | IC50 | - | — | - | |
| CHEMBL1956295 | — | IC50 | - | — | - | |
| CHEMBL1956296 | — | IC50 | - | — | - | |
| CHEMBL1956297 | — | IC50 | - | — | - | |
| CHEMBL1956298 | — | IC50 | - | — | - | |
| CHEMBL1956270 | — | IC50 | - | — | - | |
| CHEMBL1956262 | — | IC50 | - | — | - | |
| CHEMBL1956263 | — | IC50 | - | — | - |