Assay Detail
Binding
CHEMBL1961263
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Inhibition of human carbonic anhydrase 9 after 6 hrs by stop-flow CO2 hydration assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.00 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957180 | — | — | 1 | 6.68 |
| CHEMBL1951641 | — | — | 1 | 6.41 |
| CHEMBL1957185 | — | — | 1 | 6.28 |
| CHEMBL1957187 | — | — | 1 | 6.21 |
| CHEMBL1957186 | — | — | 1 | 6.17 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | — | 1 | 6.14 |
| CHEMBL1955879 | — | — | 1 | 6.11 |
| CHEMBL1957175 | — | — | 1 | 6.10 |
| CHEMBL1957177 | — | — | 1 | 6.10 |
| CHEMBL1957176 | — | — | 1 | 6.07 |
| CHEMBL1957178 | — | — | 1 | 6.07 |
| CHEMBL1957184 | — | — | 1 | 6.04 |
| CHEMBL1957172 | — | — | 1 | 6.03 |
| CHEMBL1957179 | — | — | 1 | 6.02 |
| CHEMBL1957188 | — | — | 1 | 6.01 |
| CHEMBL1957183 | — | — | 1 | 5.52 |
| CHEMBL1957182 | — | — | 1 | 5.49 |
| CHEMBL1957181 | — | — | 1 | 5.49 |
| CHEMBL270672 | — | — | 1 | 5.12 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957180 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL1951641 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL1957185 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL1957187 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL1957186 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL432745 | 7-ALLYLOXYCOUMARIN | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL1955879 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL1957175 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1957177 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1957176 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL1957178 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL1957184 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL1957172 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL1957179 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL1957188 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL1957183 | — | Ki | = | 3040.0 | nM | 5.52 |
| CHEMBL1957182 | — | Ki | = | 3230.0 | nM | 5.49 |
| CHEMBL1957181 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL270672 | — | Ki | = | 7640.0 | nM | 5.12 |
| CHEMBL6466 | COUMARIN | Ki | > | 200000.0 | nM | - |