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Assay Detail

CHEMBL1961269

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human CSNK2A1/2B expressed in Escherichia coli BL21(DE3) using RRRDDDSDDD as substrate after 15 mins by scintillation counting
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Casein kinase II alpha/beta (CHEMBL3038477)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
Hundsdörfer C, Hemmerling HJ, Götz C, Totzke F, Bednarski P, Le Borgne M, Jose J.
Bioorg Med Chem (2012) 20 : 2282 -2289
PubMed 22377675 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.11 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1957190 1 6.96
CHEMBL289277 EMODIN 1 6.34
CHEMBL1957192 1 6.09
CHEMBL1957195 1 5.84
CHEMBL1957194 1 5.33
CHEMBL1957189 1 -
CHEMBL1957191 1 -
CHEMBL1957193 1 -
CHEMBL1957196 1 -
CHEMBL1957197 1 -
CHEMBL1957199 1 -
CHEMBL1957200 1 -
CHEMBL1957201 1 -
CHEMBL1957202 1 -
CHEMBL1957203 1 -
CHEMBL1957204 1 -
CHEMBL1957205 1 -
CHEMBL1957206 1 -
CHEMBL1957207 1 -
CHEMBL1957198 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1957190 IC50 = 110.0 nM 6.96
CHEMBL289277 EMODIN IC50 = 460.0 nM 6.34
CHEMBL1957192 IC50 = 820.0 nM 6.09
CHEMBL1957195 IC50 = 1440.0 nM 5.84
CHEMBL1957194 IC50 = 4660.0 nM 5.33
CHEMBL1957189 IC50 - -
CHEMBL1957191 IC50 - -
CHEMBL1957193 IC50 - -
CHEMBL1957196 IC50 - -
CHEMBL1957197 IC50 - -
CHEMBL1957199 IC50 - -
CHEMBL1957200 IC50 - -
CHEMBL1957201 IC50 - -
CHEMBL1957202 IC50 - -
CHEMBL1957203 IC50 - -
CHEMBL1957204 IC50 - -
CHEMBL1957205 IC50 - -
CHEMBL1957206 IC50 - -
CHEMBL1957207 IC50 - -
CHEMBL1957198 IC50 - -