Assay Detail
Functional
CHEMBL1961319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus genotype 1b 1389 infected in human HuH5.2 cells assessed as inhibition of viral replication after 72 hrs by luciferase reporter gene assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.54 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1957287 | TEGOBUVIR | 2.0 | 1 | 9.15 |
| CHEMBL490672 | FILIBUVIR | 3.0 | 1 | 7.39 |
| CHEMBL1957275 | — | — | 1 | 5.73 |
| CHEMBL1957283 | — | — | 1 | 5.53 |
| CHEMBL1957273 | — | — | 1 | 5.38 |
| CHEMBL1957284 | — | — | 1 | 5.23 |
| CHEMBL1957286 | — | — | 1 | 5.15 |
| CHEMBL1957281 | — | — | 1 | 5.11 |
| CHEMBL1957274 | — | — | 1 | 5.10 |
| CHEMBL1957278 | — | — | 1 | 5.00 |
| CHEMBL1957277 | — | — | 1 | 4.74 |
| CHEMBL1957276 | — | — | 1 | 4.71 |
| CHEMBL1957285 | — | — | 1 | 4.70 |
| CHEMBL1957282 | — | — | 1 | 4.59 |
| CHEMBL1957272 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1957287 | TEGOBUVIR | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL490672 | FILIBUVIR | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1957275 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL1957283 | — | EC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL1957273 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL1957284 | — | EC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL1957286 | — | EC50 | = | 7070.0 | nM | 5.15 |
| CHEMBL1957281 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1957274 | — | EC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL1957278 | — | EC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1957277 | — | EC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL1957276 | — | EC50 | = | 19700.0 | nM | 4.71 |
| CHEMBL1957285 | — | EC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL1957282 | — | EC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1957272 | — | EC50 | - | — | - |