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Assay Detail

CHEMBL1963930

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay. (Class of assay: confirmatory)
ChEMBL ↗
166
Total Activities
166
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 166 5.55 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1410244 — — 1 6.50
CHEMBL1271266 — — 1 6.47
CHEMBL1329712 — — 1 6.43
CHEMBL1724282 — — 1 6.42
CHEMBL1350887 — — 1 6.39
CHEMBL1504939 — — 1 6.37
CHEMBL1370165 — — 1 6.35
CHEMBL1461216 — — 1 6.34
CHEMBL1433062 — — 1 6.33
CHEMBL28721 — — 1 6.29
CHEMBL1503182 — — 1 6.28
CHEMBL1304345 — — 1 6.22
CHEMBL1569991 — — 1 6.22
CHEMBL1463248 — — 1 6.18
CHEMBL1385949 — — 1 6.17
CHEMBL1489399 — — 1 6.15
CHEMBL1381413 — — 1 6.13
CHEMBL1580036 — — 1 6.11
CHEMBL1453902 — — 1 6.11
CHEMBL1432675 — — 1 6.11
CHEMBL1485717 — — 1 6.07
CHEMBL1421470 — — 1 6.05
CHEMBL1714422 — — 1 6.03
CHEMBL1353918 — — 1 6.03
CHEMBL1964442 — — 1 6.02
CHEMBL1340607 — — 1 6.00
CHEMBL220259 — — 1 5.98
CHEMBL1445488 — — 1 5.97
CHEMBL1511981 — — 1 5.96
CHEMBL1331149 — — 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1410244 — IC50 = 318.0 nM 6.50
CHEMBL1271266 — IC50 = 335.0 nM 6.47
CHEMBL1329712 — IC50 = 368.0 nM 6.43
CHEMBL1724282 — IC50 = 376.0 nM 6.42
CHEMBL1350887 — IC50 = 409.0 nM 6.39
CHEMBL1504939 — IC50 = 431.0 nM 6.37
CHEMBL1370165 — IC50 = 443.0 nM 6.35
CHEMBL1461216 — IC50 = 456.0 nM 6.34
CHEMBL1433062 — IC50 = 469.0 nM 6.33
CHEMBL28721 — IC50 = 518.0 nM 6.29
CHEMBL1503182 — IC50 = 526.0 nM 6.28
CHEMBL1569991 — IC50 = 599.0 nM 6.22
CHEMBL1304345 — IC50 = 603.0 nM 6.22
CHEMBL1463248 — IC50 = 665.0 nM 6.18
CHEMBL1385949 — IC50 = 676.0 nM 6.17
CHEMBL1489399 — IC50 = 712.0 nM 6.15
CHEMBL1381413 — IC50 = 738.0 nM 6.13
CHEMBL1453902 — IC50 = 770.0 nM 6.11
CHEMBL1580036 — IC50 = 776.0 nM 6.11
CHEMBL1432675 — IC50 = 771.0 nM 6.11
CHEMBL1485717 — IC50 = 843.0 nM 6.07
CHEMBL1421470 — IC50 = 891.0 nM 6.05
CHEMBL1714422 — IC50 = 933.0 nM 6.03
CHEMBL1353918 — IC50 = 934.0 nM 6.03
CHEMBL1964442 — IC50 = 952.0 nM 6.02
CHEMBL1340607 — IC50 = 999.0 nM 6.00
CHEMBL220259 — IC50 = 1040.0 nM 5.98
CHEMBL1445488 — IC50 = 1080.0 nM 5.97
CHEMBL1331149 — IC50 = 1100.0 nM 5.96
CHEMBL1511981 — IC50 = 1110.0 nM 5.96
CHEMBL1721094 — IC50 = 1130.0 nM 5.95
CHEMBL1478082 — IC50 = 1130.0 nM 5.95
CHEMBL1489711 — IC50 = 1150.0 nM 5.94
CHEMBL1608642 — IC50 = 1200.0 nM 5.92
CHEMBL1991440 — IC50 = 1250.0 nM 5.90
CHEMBL1528986 — IC50 = 1290.0 nM 5.89
CHEMBL1993173 — IC50 = 1370.0 nM 5.86
CHEMBL1898589 — IC50 = 1450.0 nM 5.84
CHEMBL1467623 — IC50 = 1510.0 nM 5.82
CHEMBL1586360 — IC50 = 1510.0 nM 5.82
CHEMBL1359614 — IC50 = 1500.0 nM 5.82
CHEMBL1383966 — IC50 = 1530.0 nM 5.82
CHEMBL1550032 — IC50 = 1550.0 nM 5.81
CHEMBL1991021 — IC50 = 1650.0 nM 5.78
CHEMBL1314093 — IC50 = 1710.0 nM 5.77
CHEMBL1505300 — IC50 = 1710.0 nM 5.77
CHEMBL1421970 — IC50 = 1810.0 nM 5.74
CHEMBL1224683 — IC50 = 1810.0 nM 5.74
CHEMBL1405203 — IC50 = 1880.0 nM 5.73
CHEMBL1506538 — IC50 = 1890.0 nM 5.72