Assay Detail
Binding
CHEMBL2013514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6-histine tagged Bacillus anthracis LF 263-C terminal catalytic domain using MCA-KKVYPYPME-Dap(Dnp)-NH2 as substrate after 4 hrs by FRET analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus anthracis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 9.45 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012752 | — | — | 1 | 10.40 |
| CHEMBL2012753 | — | — | 1 | 9.96 |
| CHEMBL1760324 | — | — | 1 | 9.89 |
| CHEMBL2012836 | — | — | 1 | 9.77 |
| CHEMBL2012832 | — | — | 1 | 9.64 |
| CHEMBL1269994 | — | — | 1 | 9.62 |
| CHEMBL2012838 | — | — | 1 | 9.57 |
| CHEMBL2012750 | — | — | 1 | 9.52 |
| CHEMBL2010824 | — | — | 1 | 9.51 |
| CHEMBL2012751 | — | — | 1 | 9.31 |
| CHEMBL1760318 | — | — | 1 | 9.24 |
| CHEMBL2012834 | — | — | 1 | 9.22 |
| CHEMBL2012837 | — | — | 1 | 9.00 |
| CHEMBL1760322 | — | — | 1 | 8.92 |
| CHEMBL2012833 | — | — | 1 | 8.89 |
| CHEMBL2012835 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012752 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL2012753 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL1760324 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL2012836 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL2012832 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1269994 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL2012838 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL2012750 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2010824 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL2012751 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL1760318 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL2012834 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL2012837 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1760322 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2012833 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2012835 | — | Ki | = | 2.0 | nM | 8.70 |