Assay Detail
Binding
CHEMBL2013523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760322 | — | — | 1 | 6.10 |
| CHEMBL2012836 | — | — | 1 | 6.02 |
| CHEMBL1269994 | — | — | 1 | 5.91 |
| CHEMBL1760318 | — | — | 1 | 5.70 |
| CHEMBL2012837 | — | — | 1 | 5.57 |
| CHEMBL1760324 | — | — | 1 | 5.33 |
| CHEMBL2012838 | — | — | 1 | 5.00 |
| CHEMBL2010824 | — | — | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760322 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL2012836 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1269994 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL1760318 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2012837 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1760324 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2012838 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2010824 | — | IC50 | = | 13300.0 | nM | 4.88 |