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Assay Detail

CHEMBL2013616

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Physicochemical
Inhibition of advanced glycation end-products formation after 14 days by spectrofluorimetry
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Physicochemical
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Publication

Chemical constituents from the aerial parts of Aster koraiensis with protein glycation and aldose reductase inhibitory activities.
Lee J, Lee YM, Lee BW, Kim JH, Kim JS.
J Nat Prod (2012) 75 : 267 -270
PubMed 22264115 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.98 5.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL177126 1 5.19
CHEMBL249447 1 5.18
CHEMBL234316 2 5.09
CHEMBL464507 GUAJAVERIN 1 5.05
CHEMBL250450 ISOQUERCETIN 2.0 1 5.04
CHEMBL284616 CHLOROGENIC ACID 2.0 1 -
CHEMBL258394 NARCISSIN 1 -
CHEMBL498879 NICOTIFLOROSIDE 1 -
CHEMBL225304 PIMAGEDINE 2.0 1 -
CHEMBL2011519 1 -
CHEMBL506678 SITOGLUSIDE 2.0 1 -
CHEMBL487783 1 -
CHEMBL463487 CITRUSIN C 1 -
CHEMBL501416 GYMNASTERKOREAYNE E 1 -
CHEMBL463634 GYMNASTERKOREAYNE A 1 -
CHEMBL2011645 1 -
CHEMBL2011644 1 -
CHEMBL2011643 1 -
CHEMBL56337 EPALRESTAT 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL177126 IC50 = 6400.0 nM 5.19
CHEMBL249447 IC50 = 6600.0 nM 5.18
CHEMBL234316 IC50 = 8200.0 nM 5.09
CHEMBL464507 GUAJAVERIN IC50 = 9000.0 nM 5.05
CHEMBL250450 ISOQUERCETIN IC50 = 9200.0 nM 5.04
CHEMBL234316 IC50 = 44400.0 nM 4.35
CHEMBL284616 CHLOROGENIC ACID IC50 > 50000.0 nM -
CHEMBL258394 NARCISSIN IC50 > 50000.0 nM -
CHEMBL498879 NICOTIFLOROSIDE IC50 > 50000.0 nM -
CHEMBL225304 PIMAGEDINE IC50 = 965900.0 nM -
CHEMBL2011519 IC50 > 50000.0 nM -
CHEMBL506678 SITOGLUSIDE IC50 > 50000.0 nM -
CHEMBL487783 IC50 > 50000.0 nM -
CHEMBL463487 CITRUSIN C IC50 > 50000.0 nM -
CHEMBL501416 GYMNASTERKOREAYNE E IC50 > 50000.0 nM -
CHEMBL463634 GYMNASTERKOREAYNE A IC50 > 50000.0 nM -
CHEMBL2011645 IC50 > 50000.0 nM -
CHEMBL2011644 IC50 > 50000.0 nM -
CHEMBL2011643 IC50 > 50000.0 nM -
CHEMBL56337 EPALRESTAT IC50 > 50000.0 nM -