Assay Detail
Binding
CHEMBL2013618
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Inhibition of human His6-tagged DNA polymerase gamma expressed using baculovirus assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.15 | 4.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011646 | PINOPHILIN A | — | 1 | 4.25 |
| CHEMBL2011648 | — | — | 1 | 4.17 |
| CHEMBL2011647 | PINOPHILIN B | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011646 | PINOPHILIN A | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL2011648 | — | IC50 | = | 67300.0 | nM | 4.17 |
| CHEMBL2011647 | PINOPHILIN B | IC50 | = | 93700.0 | nM | 4.03 |