Assay Detail
Binding
CHEMBL2013620
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DNA polymerase delta assessed as inhibition of incorporation of dTTP into poly(dA)/oligo(dT)18 after 60 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA polymerase delta catalytic subunit (CHEMBL2735) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.15 | 4.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2011646 | PINOPHILIN A | — | 1 | 4.26 |
| CHEMBL2011648 | — | — | 1 | 4.17 |
| CHEMBL2011647 | PINOPHILIN B | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2011646 | PINOPHILIN A | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL2011648 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL2011647 | PINOPHILIN B | IC50 | = | 96400.0 | nM | 4.02 |