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Assay Detail

CHEMBL2013652

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human GSK-3beta using biotin-AAEELDSRAGS(PO3H2)PQL as substrate after 20 mins by liquid scintillation counting
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Glycogen synthase kinase-3 beta (CHEMBL262)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
Hicks JW, Wilson AA, Rubie EA, Woodgett JR, Houle S, Vasdev N.
Bioorg Med Chem Lett (2012) 22 : 2099 -2101
PubMed 22321216 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.42 7.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL259850 1 7.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL259850 Ki = 38.0 nM 7.42