Assay Detail
Binding
CHEMBL2013769
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Inhibition of Chk1
52
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 52 | 7.35 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1223526 | — | — | 1 | 10.00 |
| CHEMBL2012879 | — | — | 1 | 8.52 |
| CHEMBL2012859 | — | — | 1 | 8.40 |
| CHEMBL2012858 | — | — | 1 | 8.30 |
| CHEMBL2012857 | — | — | 1 | 8.22 |
| CHEMBL487273 | — | — | 1 | 8.15 |
| CHEMBL2012852 | — | — | 1 | 8.05 |
| CHEMBL2012877 | — | — | 1 | 8.00 |
| CHEMBL1223456 | — | — | 1 | 8.00 |
| CHEMBL2012856 | — | — | 1 | 8.00 |
| CHEMBL2012863 | — | — | 1 | 8.00 |
| CHEMBL2012878 | — | — | 1 | 8.00 |
| CHEMBL2012853 | — | — | 1 | 7.70 |
| CHEMBL1223524 | — | — | 1 | 7.70 |
| CHEMBL2012882 | — | — | 1 | 7.70 |
| CHEMBL2012881 | — | — | 1 | 7.70 |
| CHEMBL2012880 | — | — | 1 | 7.70 |
| CHEMBL2012860 | — | — | 1 | 7.70 |
| CHEMBL2012850 | — | — | 1 | 7.70 |
| CHEMBL2012842 | — | — | 1 | 7.70 |
| CHEMBL2012841 | — | — | 1 | 7.70 |
| CHEMBL2012883 | — | — | 1 | 7.52 |
| CHEMBL2012872 | — | — | 1 | 7.52 |
| CHEMBL2012870 | — | — | 1 | 7.52 |
| CHEMBL2012861 | — | — | 1 | 7.52 |
| CHEMBL2012848 | — | — | 1 | 7.52 |
| CHEMBL2012865 | — | — | 1 | 7.52 |
| CHEMBL2012847 | — | — | 1 | 7.40 |
| CHEMBL2012855 | — | — | 1 | 7.40 |
| CHEMBL2012862 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1223526 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL2012879 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2012859 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2012858 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2012857 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL487273 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2012852 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2012877 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1223456 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012856 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012863 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012878 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2012841 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1223524 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012882 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012881 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012880 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012860 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012853 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012850 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012842 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012865 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012848 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012861 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012872 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012883 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012870 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2012847 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2012855 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2012862 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2012868 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2012884 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2012871 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2012874 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2012866 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2012843 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2012864 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL452021 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2012839 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2012875 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2012873 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2012854 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2012867 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2012876 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2012840 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2012844 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2012845 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL2012846 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2012851 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL487274 | — | IC50 | = | 800.0 | nM | 6.10 |