Assay Detail
Functional
CHEMBL2013772
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Inhibition of cell cycle arrest in human HT-29 cells assessed as abrogation at G2/M checkpoint measuring phosphohistone-H3 level
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.29 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012863 | — | — | 1 | 5.89 |
| CHEMBL2012861 | — | — | 1 | 5.77 |
| CHEMBL2012878 | — | — | 1 | 5.60 |
| CHEMBL2012881 | — | — | 1 | 5.57 |
| CHEMBL2012859 | — | — | 1 | 5.51 |
| CHEMBL2012884 | — | — | 1 | 5.43 |
| CHEMBL2012880 | — | — | 1 | 5.42 |
| CHEMBL2012857 | — | — | 1 | 5.33 |
| CHEMBL2012879 | — | — | 1 | 5.32 |
| CHEMBL2012877 | — | — | 1 | 5.30 |
| CHEMBL2012882 | — | — | 1 | 5.28 |
| CHEMBL2012883 | — | — | 1 | 5.28 |
| CHEMBL2012858 | — | — | 1 | 5.20 |
| CHEMBL2012856 | — | — | 1 | 4.89 |
| CHEMBL2012862 | — | — | 1 | 4.89 |
| CHEMBL2012864 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012863 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2012861 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2012878 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2012881 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL2012859 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2012884 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2012880 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2012857 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2012879 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2012877 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2012882 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2012883 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2012858 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2012856 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2012862 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2012864 | — | EC50 | = | 100000.0 | nM | 4.00 |