Assay Detail
Functional
CHEMBL2013837
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Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.35 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 5.19 |
| CHEMBL2012417 | PHOYUNBENE B | — | 1 | 4.43 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.09 |
| CHEMBL2012418 | PHOYUNBENE C | — | 1 | 4.04 |
| CHEMBL99852 | — | — | 1 | 4.02 |
| CHEMBL2012416 | PHOYUNBENE A | — | 1 | - |
| CHEMBL2012419 | PHOYUNBENE D | — | 1 | - |
| CHEMBL2012420 | PHOYUNBENE E | — | 1 | - |
| CHEMBL2012421 | PHOYUNBENE F | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL2012417 | PHOYUNBENE B | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL165 | RESVERATROL | IC50 | = | 80300.0 | nM | 4.09 |
| CHEMBL2012418 | PHOYUNBENE C | IC50 | = | 90800.0 | nM | 4.04 |
| CHEMBL99852 | — | IC50 | = | 95800.0 | nM | 4.02 |
| CHEMBL2012416 | PHOYUNBENE A | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012419 | PHOYUNBENE D | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012420 | PHOYUNBENE E | IC50 | > | 100000.0 | nM | - |
| CHEMBL2012421 | PHOYUNBENE F | IC50 | > | 100000.0 | nM | - |