Assay Detail
Functional
CHEMBL2013942
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Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 8.52 |
| CHEMBL2013251 | — | — | 1 | 7.35 |
| CHEMBL2010937 | — | — | 1 | 6.48 |
| CHEMBL2010939 | — | — | 1 | 5.90 |
| CHEMBL2010934 | — | — | 1 | 5.80 |
| CHEMBL2013247 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2013251 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2010937 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2010939 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2010934 | — | IC50 | = | 1595.0 | nM | 5.80 |
| CHEMBL2013247 | — | IC50 | = | 2950.0 | nM | 5.53 |