Assay Detail
Binding
CHEMBL2013944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sheep brain tubulin polymerization after 15 mins by turbidimetry analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.68 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | — | 1 | 5.50 |
| CHEMBL2013251 | — | — | 1 | 4.92 |
| CHEMBL2013248 | — | — | 1 | 4.89 |
| CHEMBL2010937 | — | — | 1 | 4.43 |
| CHEMBL2013249 | — | — | 1 | 4.22 |
| CHEMBL2013247 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63970 | DESOXYPODOPHYLLOTOXIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2013251 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2013248 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL2010937 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL2013249 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL2013247 | — | IC50 | = | 80000.0 | nM | 4.10 |