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Assay Detail

CHEMBL2014033

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Porphyromonas gingivalis recombinant SerB653 phosphatase expressed in Escherichia coli BL21 using phosphoserine as substrate after 1 hr by malachite green colorimetric assay
ChEMBL ↗
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Porphyromonas gingivalis
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis.
Jung SK, Ko Y, Yu KR, Kim JH, Lee JY, Chae CH, Ji S, Kim CH, Lee HK, Choi EB, Kim BY, Erikson RL, Chung SJ, Kim SJ.
Bioorg Med Chem Lett (2012) 22 : 2084 -2088
PubMed 22326397 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 4.86 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2012432 — — 1 5.55
CHEMBL2012425 — — 1 5.40
CHEMBL2012426 — — 1 5.26
CHEMBL2012427 — — 1 5.16
CHEMBL490503 — — 1 5.16
CHEMBL2012455 — — 1 5.16
CHEMBL2012456 — — 1 5.12
CHEMBL2012450 — — 1 5.10
CHEMBL2012451 — — 1 5.04
CHEMBL2012433 — — 1 4.95
CHEMBL2012428 — — 1 4.94
CHEMBL2012452 — — 1 4.94
CHEMBL2012439 — — 1 4.91
CHEMBL2012434 — — 1 4.90
CHEMBL2012458 — — 1 4.84
CHEMBL2012444 — — 1 4.79
CHEMBL2012453 — — 1 4.78
CHEMBL2012440 — — 1 4.78
CHEMBL2012457 — — 1 4.78
CHEMBL2012435 — — 1 4.77
CHEMBL2012436 — — 1 4.75
CHEMBL2010820 — — 1 4.75
CHEMBL2012459 — — 1 4.75
CHEMBL2012437 — — 1 4.73
CHEMBL2012446 — — 1 4.73
CHEMBL2012445 — — 1 4.73
CHEMBL2012422 — — 1 4.73
CHEMBL2012438 — — 1 4.73
CHEMBL2012466 — — 1 4.73
CHEMBL523140 — — 1 4.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2012432 — IC50 = 2800.0 nM 5.55
CHEMBL2012425 — IC50 = 4000.0 nM 5.40
CHEMBL2012426 — IC50 = 5500.0 nM 5.26
CHEMBL2012427 — IC50 = 6900.0 nM 5.16
CHEMBL490503 — IC50 = 7000.0 nM 5.16
CHEMBL2012455 — IC50 = 7000.0 nM 5.16
CHEMBL2012456 — IC50 = 7500.0 nM 5.12
CHEMBL2012450 — IC50 = 8000.0 nM 5.10
CHEMBL2012451 — IC50 = 9200.0 nM 5.04
CHEMBL2012433 — IC50 = 11300.0 nM 4.95
CHEMBL2012452 — IC50 = 11500.0 nM 4.94
CHEMBL2012428 — IC50 = 11600.0 nM 4.94
CHEMBL2012439 — IC50 = 12300.0 nM 4.91
CHEMBL2012434 — IC50 = 12600.0 nM 4.90
CHEMBL2012458 — IC50 = 14500.0 nM 4.84
CHEMBL2012444 — IC50 = 16300.0 nM 4.79
CHEMBL2012453 — IC50 = 16700.0 nM 4.78
CHEMBL2012440 — IC50 = 16500.0 nM 4.78
CHEMBL2012457 — IC50 = 16800.0 nM 4.78
CHEMBL2012435 — IC50 = 17000.0 nM 4.77
CHEMBL2012459 — IC50 = 17600.0 nM 4.75
CHEMBL2012436 — IC50 = 17600.0 nM 4.75
CHEMBL2010820 — IC50 = 17900.0 nM 4.75
CHEMBL2012437 — IC50 = 18700.0 nM 4.73
CHEMBL2012446 — IC50 = 18800.0 nM 4.73
CHEMBL2012445 — IC50 = 18700.0 nM 4.73
CHEMBL2012422 — IC50 = 18800.0 nM 4.73
CHEMBL2012438 — IC50 = 18700.0 nM 4.73
CHEMBL2012466 — IC50 = 18600.0 nM 4.73
CHEMBL523140 — IC50 = 18600.0 nM 4.73
CHEMBL2012442 — IC50 = 19100.0 nM 4.72
CHEMBL2012423 — IC50 = 19000.0 nM 4.72
CHEMBL2012441 — IC50 = 19000.0 nM 4.72
CHEMBL2012447 — IC50 = 18900.0 nM 4.72
CHEMBL2012443 — IC50 = 19100.0 nM 4.72
CHEMBL2012449 — IC50 = 19600.0 nM 4.71
CHEMBL2012448 — IC50 = 19300.0 nM 4.71
CHEMBL2012454 — IC50 = 19300.0 nM 4.71
CHEMBL2012430 — IC50 = 19600.0 nM 4.71
CHEMBL2012429 — IC50 = 19400.0 nM 4.71
CHEMBL2012424 — IC50 = 19600.0 nM 4.71
CHEMBL2012536 — IC50 = 19300.0 nM 4.71
CHEMBL491898 — IC50 = 19400.0 nM 4.71
CHEMBL2012431 — IC50 = 19800.0 nM 4.70