Assay Detail
Binding
CHEMBL2014034
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Porphyromonas gingivalis recombinant SerB653 phosphatase expressed in Escherichia coli BL21 using phosphoserine as substrate measured every 10 secs by malachite green colorimetric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Porphyromonas gingivalis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.57 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2012432 | — | — | 1 | 6.00 |
| CHEMBL2012425 | — | — | 1 | 5.85 |
| CHEMBL2012426 | — | — | 1 | 5.70 |
| CHEMBL2012427 | — | — | 1 | 5.60 |
| CHEMBL490503 | — | — | 1 | 5.60 |
| CHEMBL2012455 | — | — | 1 | 5.60 |
| CHEMBL2012456 | — | — | 1 | 5.57 |
| CHEMBL2012450 | — | — | 1 | 5.54 |
| CHEMBL2012451 | — | — | 1 | 5.48 |
| CHEMBL2012433 | — | — | 1 | 5.40 |
| CHEMBL2012428 | — | — | 1 | 5.39 |
| CHEMBL2012452 | — | — | 1 | 5.39 |
| CHEMBL2012434 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2012432 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL2012425 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL2012426 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL2012427 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL490503 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2012455 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL2012456 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL2012450 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL2012451 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL2012433 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL2012428 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2012452 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2012434 | — | Ki | = | 4500.0 | nM | 5.35 |