Assay Detail
Binding
CHEMBL2014102
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Inhibition of Staphylococcus aureus peptide deformylase using N-formylmethionine-alanine-serine as substrate by spectrophotometry
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.08 | 7.70 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308333 | ACTINONIN | — | 1 | 7.70 |
| CHEMBL2012550 | FLAVIMYCIN A | — | 2 | 4.45 |
| CHEMBL2012551 | FLAVIMYCIN B | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308333 | ACTINONIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2012550 | FLAVIMYCIN A | IC50 | = | 35800.0 | nM | 4.45 |
| CHEMBL2012550 | FLAVIMYCIN A | Inhibition | - | % | - | |
| CHEMBL2012551 | FLAVIMYCIN B | Inhibition | - | % | - | |
| CHEMBL2012551 | FLAVIMYCIN B | IC50 | = | 100100.0 | nM | - |