Assay Detail
Binding
CHEMBL2014325
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Inhibition of TNFalpha-induced NFkappaB transcriptional activity in human HepG2 cells pretreated for 1 hr before TNFalpha challenge by luciferase reporter gene analysis
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.36 | 6.05 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | 4.0 | 1 | 6.05 |
| CHEMBL2011545 | — | — | 2 | 5.19 |
| CHEMBL43469 | ASARININ | — | 2 | 5.15 |
| CHEMBL252915 | SESAMIN | — | 2 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421 | SULFASALAZINE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2011545 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL43469 | ASARININ | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL252915 | SESAMIN | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2011545 | — | Inhibition | - | % | - | |
| CHEMBL252915 | SESAMIN | Inhibition | - | % | - | |
| CHEMBL43469 | ASARININ | Inhibition | - | % | - |