Assay Detail
Binding
CHEMBL2014328
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Transactivation of PPAR expressed in HepG2 cells after 20 hrs by luminescence assay
20
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.12 | 5.98 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 5.98 |
| CHEMBL2011539 | PLUVIATILOL | — | 2 | 5.77 |
| CHEMBL2011544 | — | — | 2 | 5.70 |
| CHEMBL2011541 | — | — | 2 | 5.37 |
| CHEMBL2011538 | — | — | 2 | 5.21 |
| CHEMBL487611 | PINORESINOL | — | 2 | 4.99 |
| CHEMBL2011543 | — | — | 2 | 4.69 |
| CHEMBL2011540 | PIPERITOL | — | 2 | 4.68 |
| CHEMBL108861 | METHYLEUGENOL | — | 1 | 4.55 |
| CHEMBL2011545 | — | — | 1 | 4.23 |
| CHEMBL252915 | SESAMIN | — | 1 | - |
| CHEMBL43469 | ASARININ | — | 1 | - |
| CHEMBL2011542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL2011539 | PLUVIATILOL | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2011544 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2011541 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2011538 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL487611 | PINORESINOL | EC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL2011543 | — | EC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL2011540 | PIPERITOL | EC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL108861 | METHYLEUGENOL | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL2011545 | — | EC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL2011544 | — | Activity | - | — | - | |
| CHEMBL2011543 | — | Activity | - | — | - | |
| CHEMBL2011541 | — | Activity | - | — | - | |
| CHEMBL2011540 | PIPERITOL | Activity | - | — | - | |
| CHEMBL487611 | PINORESINOL | Activity | - | — | - | |
| CHEMBL2011539 | PLUVIATILOL | Activity | - | — | - | |
| CHEMBL2011538 | — | Activity | - | — | - | |
| CHEMBL252915 | SESAMIN | EC50 | > | 60000.0 | nM | - |
| CHEMBL43469 | ASARININ | EC50 | > | 60000.0 | nM | - |
| CHEMBL2011542 | — | EC50 | > | 60000.0 | nM | - |