Assay Detail
Functional
CHEMBL2014342
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against ACV-resistant TK-deficient HSV-1 KOS infected in HEL cells assessed as inhibition of viral-induced cytopathogenicity
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 4'-Ethynyl-2'-deoxy-4'-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.51 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 6.00 |
| CHEMBL2012667 | — | — | 1 | 5.60 |
| CHEMBL2012669 | — | — | 1 | 5.35 |
| CHEMBL2012668 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2012667 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2012669 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2012668 | — | EC50 | = | 8000.0 | nM | 5.10 |